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Continuous Drug Infusion for Diabetes Therapy: A Closed-Loop Control System Design
EURASIP Journal on Wireless Communications and Networking volume 2008, Article number: 495185 (2007)
Abstract
While a typical way for diabetes therapy is discrete insulin infusion based on long-time interval measurement, in this paper, we design a closed-loop control system for continuous drug infusion to improve the traditional discrete methods and make diabetes therapy automatic in practice. By exploring the accumulative function of drug to insulin, a continuous injection model is proposed. Based on this model, proportional-integral-derivative (PID) and fuzzy logic controllers are designed to tackle a control problem of the resulting highly nonlinear plant. Even with serious disturbance of glucose, such as nutrition absorption at meal time, the proposed scheme can perform well in simulation experiments.
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Chen, J., Cao, K., Sun, Y. et al. Continuous Drug Infusion for Diabetes Therapy: A Closed-Loop Control System Design. J Wireless Com Network 2008, 495185 (2007). https://doi.org/10.1155/2008/495185
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DOI: https://doi.org/10.1155/2008/495185