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Continuous Drug Infusion for Diabetes Therapy: A Closed-Loop Control System Design


While a typical way for diabetes therapy is discrete insulin infusion based on long-time interval measurement, in this paper, we design a closed-loop control system for continuous drug infusion to improve the traditional discrete methods and make diabetes therapy automatic in practice. By exploring the accumulative function of drug to insulin, a continuous injection model is proposed. Based on this model, proportional-integral-derivative (PID) and fuzzy logic controllers are designed to tackle a control problem of the resulting highly nonlinear plant. Even with serious disturbance of glucose, such as nutrition absorption at meal time, the proposed scheme can perform well in simulation experiments.

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Correspondence to Jiming Chen.

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Open Access This article is distributed under the terms of the Creative Commons Attribution 2.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Chen, J., Cao, K., Sun, Y. et al. Continuous Drug Infusion for Diabetes Therapy: A Closed-Loop Control System Design. J Wireless Com Network 2008, 495185 (2007).

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  • Control Problem
  • Fuzzy Logic
  • Simulation Experiment
  • System Application
  • Insulin Infusion