- Research Article
- Open Access
Continuous Drug Infusion for Diabetes Therapy: A Closed-Loop Control System Design
© Jiming Chen et al. 2008
Received: 15 July 2007
Accepted: 5 December 2007
Published: 25 December 2007
While a typical way for diabetes therapy is discrete insulin infusion based on long-time interval measurement, in this paper, we design a closed-loop control system for continuous drug infusion to improve the traditional discrete methods and make diabetes therapy automatic in practice. By exploring the accumulative function of drug to insulin, a continuous injection model is proposed. Based on this model, proportional-integral-derivative (PID) and fuzzy logic controllers are designed to tackle a control problem of the resulting highly nonlinear plant. Even with serious disturbance of glucose, such as nutrition absorption at meal time, the proposed scheme can perform well in simulation experiments.
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