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Open Access

Continuous Drug Infusion for Diabetes Therapy: A Closed-Loop Control System Design

  • Jiming Chen1Email author,
  • Kejie Cao1,
  • Youxian Sun1,
  • Yang Xiao2 and
  • Xu(Kevin) Su3
EURASIP Journal on Wireless Communications and Networking20072008:495185

Received: 15 July 2007

Accepted: 5 December 2007

Published: 25 December 2007


While a typical way for diabetes therapy is discrete insulin infusion based on long-time interval measurement, in this paper, we design a closed-loop control system for continuous drug infusion to improve the traditional discrete methods and make diabetes therapy automatic in practice. By exploring the accumulative function of drug to insulin, a continuous injection model is proposed. Based on this model, proportional-integral-derivative (PID) and fuzzy logic controllers are designed to tackle a control problem of the resulting highly nonlinear plant. Even with serious disturbance of glucose, such as nutrition absorption at meal time, the proposed scheme can perform well in simulation experiments.


Control ProblemFuzzy LogicSimulation ExperimentSystem ApplicationInsulin Infusion

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Authors’ Affiliations

State Key Laboratory of Industrial Control Technology, Institute of Industrial Process Control, Zhejiang University, Hangzhou, China
Department of Computer Science, The University of Alabama, Tuscaloosa, USA
Department of Computer Science, University of Texas at San Antonio, San Antonio, USA


© Jiming Chen et al. 2008

This article is published under license to BioMed Central Ltd. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.